Immunokun (chiens – 270 g)

26,00

Aliment complémentaire pour améliorer la réponse immunitaire des chiens atteints de leishmaniose ou de faibles défenses (immunosupprimés).

  • Module la fonction du système immunitaire, protégeant contre les infections microbiennes.
  • Procure une action protectrice contre la leishmaniose (Leishmania infantum protozoan), aidant à réduire la charge parasitaire.
  • Fournit des nutriments clés pour le système immunitaire, maximisant l’activité des cellules immunitaires:
    • Fournit la source d’énergie préférée.
    • Protège du stress oxydatif lié à sa forte activité métabolique.
  • Aide à maintenir l’équilibre de la flore intestinale, empêchant la colonisation par des bactéries pathogènes.

Know more about

Available: 700 en stock

Ingredients

Yeast products (mannan-oligosaccharides – 15.6%, beta-glucans – 4.2%), fructooligosaccharides, flavoring byproduct (hydrolyzed pork and chicken liver), dried leaves of Artemisia annua (from organic farming, 4.2%).

Nutritional additives

Flavourings: L-glutamic acid – 222 220 mg/kg; Gut flora stabilisers: Enterococcus faecium  – 1.1 · 10^11 CFU/kg; Vitamins: Vitamin C – 4 440 mg/kg, Vitamin E – 33 330 IU/kg; Trace elements: Zinc (zinc chelate of glycine) – 2 222 mg/kg, Selenium (sodium selenite) – 7.8 mg/kg.

Analytical constituents

Crude protein 38.63%; Crude fibres 2.86%; Crude fat 6.81%; Crude ash 9.50%

How do its active ingredients work?

champiñones como fuente de betaglucanos

Beta-glucans

Beta-glucans are PAMP molecules (Pathogen Associated Molecular Patterns) which act as modifiers of the immune response. It activates macrophages and local dendritic cells to positively regulate MHC class II and increase the secretion of cytokines (TNF-α, IL-2, IL-10 and IL-12), which that allows them to efficiently present antigens to T lymphocytes and initiate an effective immune response. Beta-glucans stimulate a new concept called trained immunity or innate immune memory, which allows macrophages, monocytes and natural killer cells show a greater response capacity when they are reunited with pathogens, both at the digestive and systemic levels.

manojo de artemisia annua

Artemisia annua

It provides a double protective action against the protozoan Leishmania infantum. 1: Presents leishmanicidal action (apoptotic antileishmanial activity); 2: It preferentially stimulates Th1 immunity (characterized by increased levels of IFN-γ, CD4 + and CD8 + T lymphocytes, and nitrite) and suppresses Th2 immune responses with a reduced level of IL-4 and IL-10.

Glutamicok

L-glutamic acid

Precursor of glutamine, considered a conditionally essential amino acid and a key nutrient for the proper functioning of the immune system. Glutamine is the preferred energy source for immune cells, and providing greater amounts of this essential nutrient improves their function.

e.faeciumok

Enterococcus faecium

Encapsulated probiotic (technology that ensures the stability of the bacteria during the period of manufacture and conservation of the product). Enterococcus faecium modifies the immune response through two mechanisms. 1: Indirectly due to the ability to balance the intestinal microbiota. Competition for nutrients, adhesion sites and the production of antimicrobial substances (short chain fatty acids, defensins, etc.) inhibit the proliferation of pathogenic bacteria, while favoring the development of beneficial bacteria; 2: Direct effect on the immune response both innate and acquired against pathogens at the local and systemic level. Probiotics induce the maturation of dendritic cells and macrophages (increasing their phagocytic activity and their efficiency of presenting antigens to T lymphocytes), promote the production of cytokines (TNF-α and IL-6), stimulate the cellular activity of the natural killer cells and increase the response to vaccination (greater production of IgG and IgA).

mosok

Mannan-oligosaccarides

They increase the secretion of IgA in the intestine, stimulating the most important humoral immune factor in the intestinal mucosa. These inhibit the adherence, colonization and penetration of bacteria and toxins, increase mucus secretion and prevent the uptake of food antigens. In this sense, the increase in IgA at the intestinal level represents a greater local immune capacity and greater protection against the invasion of pathogens.

fosok

Fructooligosaccharides

Prebiotic component (it resists digestion and reaches the colon intact) that constitutes a source of energy, and therefore favors the proliferation, of beneficial bacteria (Lactobacillus spp, Bacteroides spp and Bifidobacterium spp). Consequently, beneficial bacteria inhibit by competition exclusive the growth of pathogenic bacteria. In addition, as a result of their fermentation, they increase the release of short-chain fatty acids (acetate, propionate, lactate and butyrate) into the intestinal lumen, reducing the presence of pathogenic bacteria (E. coli and C. perfringens), thanks to the reduction of colonic pH.

VitEok

Vitamin E

Immune cells contain particularly high concentrations of vitamin E to protect themselves from oxidative damage related to their high metabolic activity and the high content of polyunsaturated fatty acids in their membrane. Vitamin E improves the integrity of the cell membrane and positively modulates signaling events in T lymphocytes. Additionally, indirectly, vitamin E protects T cell function by reducing the production of T cell suppressor factors such as PGE2 produced by macrophages.

Vitcok

Vitamin C

It is the most powerful reducing agent available for cells. Vitamin C regenerates the enzyme glutathione, neutralizes free radicals both intracellularly and extracellularly, and protects against free radical-mediated protein inactivation associated with the oxidative breakdown of neutrophils.

Seok

Selenium

It acts as a cofactor for glutathione peroxidase, an antioxidant enzyme that protects tissues against oxidative stress, by catalyzing the reduction of hydrogen peroxides and organic hydroperoxides and by regenerating vitamin E.

Znok

Zinc

Zinc increases the activity of antioxidant enzymes such as glutathione peroxidase. It is a cofactor of the enzyme superoxide dismutase that catalyzes the conversion of superoxide radicals into H2O2, less oxidants. Zinc deficiency is a cause of dysfunction in almost all classes of immune cells, in addition to being related to the involution of the thymus.

  • Healthy animals with reduced immune system responsiveness:
    • Cubs from weaning to 6 months of age.
    • Older animals (around five years in large or giant breed dogs and around seven years in small dogs).
    • Dogs with obesity.
    • Animals under conditions of chronic stress.
    • Animals with a high level of activity: Canicross athletes, agility, dog dancing, disc dog, dock jumping, bikejoring, skijoring, herding, mushing, working dogs (shepherds, rescue, hunting), etc.
    • Lactating females.
  • Dogs positive for Leishmania or diagnosed with other infectious diseases such as parvovirus, ehrlichiosis, mange, ringworm or infectious processes of the skin and respiratory system.
  • Other diseases that cause immunosuppression:
    • Cushing's syndrome.
    • Genetic alternations such as clinical canine hematopoiesis (affects all Collie dogs with a silver gray coat), canine granulocytopathic syndrome (described in the Irish Setter), hereditary malabsorption of vitamin B12 (affects Giant Schnoauzer dogs), Neutrophilic dysfunction of Weimaraner and Doberman, etc.
  • During any vaccination.

It is not recommended the use of IMMUNOKUN in case of:

  • Patients with allergies (food or environmental allergy, allergy to flea bites, drugs, etc.).
  • Patients with acute or chronic systemic inflammatory processes such as arthritis, dermatitis, enteritis, hepatitis, pancreatitis, etc.
  • Diseases with an autoimmune component such as Adison's disease, pemphigus, lupus erythematosus, rheumatoid arthritis, glomerulonephritis and meningoencephalitis of the immune complex, myositis, etc.
  • Animals under chemotherapy or use simultaneously with pro-oxidant drugs, since the antioxidant effect of Immunokun could reduce its effectiveness.
  • Patients with epilepsy or gastritis.
  • Pregnant or lactating females.

Daily recommendation to be added to the food (on top). This dose can be divided into different shots:

Weight Spoons* Amount for
<10 kg 0.5 2 months
10-20 kg 1.0 1 month
20-30 kg 1.5 20 days
>30 kg 2.0 15 days


*9.1 g per spoon

 

¿During how much time?

  • Healthy animals with reduced immune system responsiveness: Administer half the recommended daily dose as a preventive treatment.
  • Dogs positive for Leishmania or diagnosed with other infectious diseases: It is recommended to administer it for at least 1 month and maintain it while the symptoms persist.
  • Other diseases that occur with immunosuppression: It is recommended to administer it for at least 1 month and keep it while the symptoms persist.
  • During any vaccination: 5 days before the vaccination, the same day of the vaccination and for the next 7 days.